基于fet的核酸探测传感器

FET based nucleic acid detecting sensor

Abstract

一种核酸探测传感器包括场效应晶体管、基于场效应晶体管的阈值电压的变化程度从样品中探测具有序列的目标核酸分子的探测器,以及与目标核酸分子的对应一个杂交的并固定在场效应晶体管的栅上的至少一个核酸探针分子,其中场效应晶体管的栅宽度具有由下面给出的表达式(ε
Nucleic acid detecting sensor includes field-effect transistor, detector which detects target nucleic acid molecules having sequences from sample based on degree of a variation in threshold voltage of field-effect transistor, and at least one nucleic acid probe molecule which is hybridized with corresponding one of target nucleic acid molecules, and is immobilized on gate of field-effect transistor, wherein gate width of field-effect transistor is of order of length obtained by expression given below (([epsilon]0[epsilon]rkBT/e<2>n)<1/2>, where [epsilon]0is the dielectric constant of vacuum, [epsilon]rthe relative permittivity of channel domain, kBthe Boltzmann constant, T the absolute temperature of the channel domain of FET, e the elementary charge, and n an equilibrium carrier density in the channel region in the field-effect transistor where a channel is formed.

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Cited By (8)

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    CN-105393096-AMarch 09, 2016罗伯特·博世有限公司Field-effect-transistor infrared sensor having a movable gate electrode
    CN-105393096-BJuly 18, 2017罗伯特·博世有限公司具有可活动的栅极的场效应晶体管红外传感器
    US-8981421-B2March 17, 2015Peking UniversityStrip-shaped gate-modulated tunneling field effect transistor and a preparation method thereof
    US-9054075-B2June 09, 2015Peking UniversityStrip-shaped gate tunneling field effect transistor with double-diffusion and a preparation method thereof
    WO-2014079218-A1May 30, 2014北京大学Strip-shaped gate modulated tunnel field effect transistor and method of preparing same
    WO-2014082451-A1June 05, 2014北京大学带双扩散的条形栅隧穿场效应晶体管及其制备方法